Stilbenoids from Gnetum macrostachyum attenuate human platelet aggregation and adhesion.
Phytother Res
; 26(10): 1564-8, 2012 Oct.
Article
em En
| MEDLINE
| ID: mdl-22511550
ABSTRACT
Platelets play a critical role in pathogenesis of cardiovascular disorders and strokes. The inhibition of platelet function is beneficial for the treatment and prevention of these diseases. The phytochemical investigation of stilbenoids from Gnetum macrostachyum Hook. f. led to the isolation of trans-resveratrol (1), isorhapotigenin (2), gnetol (3), bisisorhapontigenin B (4), gnetin C (5), parvifolol A (6), latifolol (7) and gnetuhainin C (8). The isolated stilbenoids were evaluated for in vitro antiplatelet activities via agonist-induced platelet aggregation and static platelet-collagen adhesion assays using washed human platelets. Compounds 1, 2 and 3 were active in the inhibition of arachidonic acid (AA)-induced platelet aggregation. Compound 2 and its dimer, compound 4, were the most active stilbenoids in thrombin-induced platelet aggregation. Moreover, compounds 4, 5 and 6, tended to be more potent than monomeric and trimeric stilbenoids in a human platelet-collagen adhesion assay under static conditions. This is the first report of the antiplatelet activity of stilbenoids isolated from G. macrostachyum.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Estilbenos
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Inibidores da Agregação Plaquetária
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Adesividade Plaquetária
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Agregação Plaquetária
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Gnetum
Limite:
Humans
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article