Hypothyroidism improves random-pattern skin flap survival in rats.
J Surg Res
; 178(1): 524-8, 2012 Nov.
Article
em En
| MEDLINE
| ID: mdl-22521221
ABSTRACT
BACKGROUND:
The protective effect of hypothyroidism against ischemic or toxic conditions has been shown in various tissues. We investigated the effect of propylthiouracil (PTU)/methimazole (MMI)-induced hypothyroidism and acute local effect of MMI on the outcome of lethal ischemia in random-pattern skin flaps. MATERIALS ANDMETHODS:
Dorsal flaps with caudal pedicles were elevated at midline and flap survival was measured at the seventh day after surgery. The first group, as control, received 1 mL of 0.9% saline solution in the flap before flap elevation. In groups 2 and 3, hypothyroidism was induced by administration of either PTU 0.05% or MMI 0.04% in drinking water. The next four groups received local injections of MMI (10, 20, 50, or 100 µg/flap) before flap elevation. Local PTU injection was ignored due to insolubility of the agent.RESULTS:
Hypothyroidism was induced in chronic PTU- and MMI-treated groups, and animals in these groups showed significant increase in their flap survival, compared to control euthyroid rats (79.47% ± 10.49% and 75.48% ± 12.93% versus 52.26% ± 5.75%, respectively, P < 0.01). Acute local treatment of skin flaps with MMI failed to significantly affect the flap survival.CONCLUSION:
This study demonstrates for the first time that hypothyroidism improves survival of random-pattern skin flaps in rats.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Propiltiouracila
/
Retalhos Cirúrgicos
/
Procedimentos Cirúrgicos Dermatológicos
/
Hipotireoidismo
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Isquemia
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Metimazol
Limite:
Animals
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article