Therapeutic apheresis in peripheral and retinal circulatory disorders.
Clin Res Cardiol Suppl
; 7: 41-4, 2012 Jun.
Article
em En
| MEDLINE
| ID: mdl-22528133
ABSTRACT
In microcirculation disorders, the therapeutic apheresis seems to have two different effects. The first, achieved after only a few sessions, is acute, consisting of drastic reduction of blood viscosity and obtained with the use of low-density lipoprotein (LDL) apheresis, rheopheresis, or fibrinogen apheresis. The second effect is long term, or chronic, and needs to be evaluated after a long course of treatment. The mechanisms underlying the chronic effect are still objects of debate and take into account the pleiotropic effects of apheresis. However, it is likely that the acute effect of apheresis mainly influences the functional components of the vascular damage, and so the derived rheological benefit might last only for a short period. The chronic effect, on the contrary, by acting on the morphological alterations of the vascular walls, requires the apheresis treatment to be prolonged for a longer period or even cycles of treatment to be programmed.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doenças Vasculares
/
Remoção de Componentes Sanguíneos
/
Microcirculação
Limite:
Humans
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article