Sensitive time-windows for susceptibility in neurodevelopmental disorders.
Trends Neurosci
; 35(6): 335-44, 2012 Jun.
Article
em En
| MEDLINE
| ID: mdl-22542246
ABSTRACT
Many neurodevelopmental disorders (NDDs) are characterized by age-dependent symptom onset and regression, particularly during early postnatal periods of life. The neurobiological mechanisms preceding and underlying these developmental cognitive and behavioral impairments are, however, not clearly understood. Recent evidence using animal models for monogenic NDDs demonstrates the existence of time-regulated windows of neuronal and synaptic impairments. We propose that these developmentally-dependent impairments can be unified into a key concept namely, time-restricted windows for impaired synaptic phenotypes exist in NDDs, akin to critical periods during normal sensory development in the brain. Existence of sensitive time-windows has significant implications for our understanding of early brain development underlying NDDs and may indicate vulnerable periods when the brain is more susceptible to current therapeutic treatments.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Fatores de Tempo
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Encéfalo
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Encefalopatias
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Envelhecimento
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Deficiências do Desenvolvimento
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Transtornos Cognitivos
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Modelos Neurológicos
Tipo de estudo:
Diagnostic_studies
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Prognostic_studies
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article