RmtF, a new member of the aminoglycoside resistance 16S rRNA N7 G1405 methyltransferase family.
Antimicrob Agents Chemother
; 56(7): 3960-2, 2012 Jul.
Article
em En
| MEDLINE
| ID: mdl-22547620
ABSTRACT
Multidrug-resistant clinical isolate Klebsiella pneumoniae BM4686 was highly resistant to 4,6-disubstituted 2-deoxystreptamines and to fortimicin. Resistance was due to the presence, on the 40-kb non-self-transferable plasmid pIP849, of the rmtF gene which was cotranscribed with the upstream aac(6')-Ib gene. The deduced RmtF protein had 25 to 46% identity with members of the N7 G1405 family of aminoglycoside resistance 16S rRNA methyltransferases.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteínas de Bactérias
/
RNA Ribossômico 16S
/
Aminoglicosídeos
/
Metiltransferases
/
Antibacterianos
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article