Secreted kinase phosphorylates extracellular proteins that regulate biomineralization.
Science
; 336(6085): 1150-3, 2012 Jun 01.
Article
em En
| MEDLINE
| ID: mdl-22582013
ABSTRACT
Protein phosphorylation is a fundamental mechanism regulating nearly every aspect of cellular life. Several secreted proteins are phosphorylated, but the kinases responsible are unknown. We identified a family of atypical protein kinases that localize within the Golgi apparatus and are secreted. Fam20C appears to be the Golgi casein kinase that phosphorylates secretory pathway proteins within S-x-E motifs. Fam20C phosphorylates the caseins and several secreted proteins implicated in biomineralization, including the small integrin-binding ligand, N-linked glycoproteins (SIBLINGs). Consequently, mutations in Fam20C cause an osteosclerotic bone dysplasia in humans known as Raine syndrome. Fam20C is thus a protein kinase dedicated to the phosphorylation of extracellular proteins.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Caseínas
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Proteínas da Matriz Extracelular
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Via Secretória
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Complexo de Golgi
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article