Naturally occurring himachalenes to benzocycloheptene amino vinyl bromide derivatives: as antidepressant molecules.
Mol Divers
; 16(2): 357-66, 2012 May.
Article
em En
| MEDLINE
| ID: mdl-22584731
ABSTRACT
A new series of benzocycloheptene amino vinyl bromide derivatives (9a-9m) were synthesized from isomeric mixture of himachalenes through two-step synthesis. The unusual structure of benzocycloheptene amino vinyl bromide derivative (9a) was confirmed by NMR and X-ray crystallography analyses. The newly synthesized amino vinyl bromide derivatives of benzocycloheptene were further evaluated for their antidepressant activities. The compound 9c had shown significant reduction in the immobility period.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Sesquiterpenos
/
Benzocicloeptenos
/
Compostos de Vinila
/
Antidepressivos
Limite:
Animals
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article