Enhanced extinction of aversive memories by high-frequency stimulation of the rat infralimbic cortex.
PLoS One
; 7(5): e35853, 2012.
Article
em En
| MEDLINE
| ID: mdl-22586453
ABSTRACT
Electrical stimulation of the rodent medial prefrontal cortex (mPFC), including the infralimbic cortex (IL), immediately prior to or during fear extinction training facilitates extinction memory. Here we examined the effects of high-frequency stimulation (HFS) of the rat IL either prior to conditioning or following retrieval of the conditioned memory, on extinction of Pavlovian fear and conditioned taste aversion (CTA). IL-HFS applied immediately after fear memory retrieval, but not three hours after retrieval or prior to conditioning, subsequently reduced freezing during fear extinction. Similarly, IL-HFS given immediately, but not three hours after, retrieval of a CTA memory reduced aversion during extinction. These data indicate that HFS of the IL may be an effective method for reducing both learned fear and learned aversion.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Córtex Pré-Frontal
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Condicionamento Psicológico
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Medo
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Memória
Limite:
Animals
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article