Analysis of stored and transplanted cord blood units from KoreaCORD: reappraisal of banking guidelines and selection strategy.
Transfusion
; 53(1): 123-7, 2013 Jan.
Article
em En
| MEDLINE
| ID: mdl-22612248
ABSTRACT
BACKGROUND:
We analyzed the characteristics of stored and transplanted cord blood (CB) units from the Korean network for public CB donation (KoreaCORD) to reassess the banking guidelines and optimize CB selection based on cell dose and human leukocyte antigen (HLA) mismatching. STUDY DESIGN ANDMETHODS:
We retrospectively reviewed data, with regard to total nucleated cell (TNC) count and HLA match in the KoreaCORD registry from August 2001 to December 2010.RESULTS:
A total of 21,914 CB units have been registered, of which 904 units (4.1%) contained less than 5 × 10(8) TNCs, which did not meet the present storage criteria for public CB banking in Korea. Although the proportion of stored CBs providing TNC of 5 × 10(8) to 7.9 × 10(8) was 45.7%, only 22.0% of all transplanted CBs were derived from these stored CBs. In the single CB transplantation setting, 79% (85/108) of CB units provided 4 × 10(7) TNCs/kg or more in the transplanted one-mismatch (1-MM) CB units and 51% (19/37) of CBs provided 6 × 10(7) TNCs/kg or more in the transplanted 2-MM CB units.CONCLUSIONS:
The minimal requirement of TNCs for banking of CB units for public banking should be evaluated and increased to support the selection of CB units with higher cell doses, especially for use in the 1- and 2-MM transplant settings.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Bancos de Sangue
/
Transplante de Células-Tronco de Sangue do Cordão Umbilical
Tipo de estudo:
Guideline
/
Observational_studies
Limite:
Humans
País como assunto:
Asia
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article