Visualizing the complex 3D geometry of the perfusion border zone in isolated rabbit heart.
Appl Opt
; 51(14): 2713-21, 2012 May 10.
Article
em En
| MEDLINE
| ID: mdl-22614494
ABSTRACT
Myocardial infarction, caused by a major blockage of a coronary artery, creates a border zone (BZ) between perfused and nonperfused tissue, which is believed to be the origin of fatal cardiac arrhythmias. We used a combination of optical clearing and polarization-sensitive optical coherence tomography to visualize a three-dimensional organization of the BZ in isolated rabbit hearts (n=5) at the microscopic level with a high spatial resolution. We found that the BZ has a complex three-dimensional structure with nonperfused areas penetrating into perfused tissue with finger-like projections. These "fingers" may play an important role in the initiation and maintenance of ventricular arrhythmias.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Tomografia de Coerência Óptica
/
Infarto do Miocárdio
Tipo de estudo:
Etiology_studies
/
Evaluation_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article