Treating hypoxia in a feeble breather with Rett syndrome.
Brain Dev
; 35(3): 270-3, 2013 Mar.
Article
em En
| MEDLINE
| ID: mdl-22617859
ABSTRACT
Rett syndrome (RS) is a unique X-linked dominant neurodevelopmental disorder affecting 1 in 10,000 females. Mutations in the MECP2 gene located on Xq28 have been identified. Many of the characteristic features evolve due to immaturity of the brain in RS. Cardiorespiratory function should be investigated early to characterise the clinical phenotype of the person with RS because each of the three cardiorespiratory phenotypes; apneustic, feeble and forceful breathers have unique and different management strategies. We report a case of a feeble breather showing a correlation between cortical function and tissue pO(2) and pCO(2). We conclude that subtle changes in the levels of blood gases significantly affect cortical function in RS.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Mecânica Respiratória
/
Síndrome de Rett
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Hipóxia
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
Limite:
Adult
/
Female
/
Humans
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article