A novel UPLC-MS/MS method for simultaneous quantification of rhein, emodin, berberine and baicalin in rat plasma and its application in a pharmacokinetic study.
Bioanalysis
; 4(10): 1205-13, 2012 Jun.
Article
em En
| MEDLINE
| ID: mdl-22651564
ABSTRACT
BACKGROUND:
Dahuang Huanglian Xiexin Decoction (DHXD) is a classical formula in traditional Chinese medicines. In this study, a novel UPLC-MS/MS method was developed for the simultaneous quantification of rhein, emodin, berberine and baicalin, the major bioactive compounds of DHXD in rat plasma.RESULTS:
The method possessed high sensitivity and ultrashort analysis time (7 min). Linearity, accuracy, precision and extraction recovery of four analytes were all satisfactory. The method was then successfully applied in a pharmacokinetic study of four bioactive components after a single oral administration of DHXD extract to rats.CONCLUSION:
The method was applicable for simultaneous bioanalysis of rhein, emodin, berberine and baicalin.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Berberina
/
Flavonoides
/
Cromatografia Líquida de Alta Pressão
/
Antraquinonas
/
Emodina
/
Espectrometria de Massas em Tandem
Tipo de estudo:
Diagnostic_studies
/
Evaluation_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article