Transfer of bone-marrow-derived mesenchymal stem cells influences vascular remodeling and calcification after balloon injury in hyperlipidemic rats.
J Biomed Biotechnol
; 2012: 165296, 2012.
Article
em En
| MEDLINE
| ID: mdl-22665980
ABSTRACT
Bone-marrow-derived mesenchymal stem cells (BM-MSCs) were found to markedly increase atherosclerotic lesion size. The aim of this paper was to investigate whether BM-MSCs contribute to vascular remodeling and calcification after balloon injury in hyperlipidemic rats. Labeled BM-MSCs were found in the lesion of hyperlipidemic rats after balloon injury. Comparing injury group, transferred BM-MSCs significantly triggered vascular negative remodeling, characterized by the changes of remodeling index (0.628 ± 0.0293 versus 0.544 ± 0.0217), neointimal area (0.078 ± 0.015 mm(2) versus 0.098 ± 0.019 mm(2)), PCNA index (23.91 ± 6.59% versus 43.11 ± 5.31%), and percentage of stenosis (18.20 ± 1.09% versus 30.58 ± 1.21%). Apparent vascular calcification was detected in medial layers at 6 weeks after balloon angioplasty, which may be associated with upregulation of bone morphogenetic protein-2 (BMP-2). Our data indicated that unselected BM-MSCs transfer may induce vascular remodeling and calcification after balloon injury in hyperlipidemic rats.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Aorta
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Células da Medula Óssea
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Angioplastia com Balão
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Células-Tronco Mesenquimais
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Calcificação Vascular
Limite:
Animals
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article