Continuous synthesis and purification by direct coupling of a flow reactor with simulated moving-bed chromatography.
Angew Chem Int Ed Engl
; 51(28): 7028-30, 2012 Jul 09.
Article
em En
| MEDLINE
| ID: mdl-22674846
ABSTRACT
Continuous synthesis meets continuous purification to produce pure products from crude reaction mixtures. In the nucleophilic aromatic substitution of 2,4-difluoronitrobenzene with morpholine the desired monosubstituted product can be continuously separated from the byproducts in a purity of over 99 % by coupling a flow reactor to a simulated moving bed (SMB) chromatography module.
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MEDLINE
Idioma:
En
Ano de publicação:
2012
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Article