Evaluation of extended release brimonidine intravitreal device in normotensive rabbit eyes.
Acta Ophthalmol
; 90(5): e344-8, 2012 Aug.
Article
em En
| MEDLINE
| ID: mdl-22676067
ABSTRACT
PURPOSE:
To evaluate the safety profile of a brimonidine extended release intravitreal implant, in normotensive rabbit eyes.METHODS:
Devices were made from hollow poly-l-lactic acid (PLA) tubes and contained hundred micrograms of brimonidine pamoate. Device was injected intravitreally in one eye of 12 New Zealand pigmented rabbits, whereas other eye was injected with a sham implant in masked fashion. Ocular examination was conducted at baseline and months 1, 3 and 6 including dilated fundus examination and electro-retinogram (ERG). Four rabbits were sacrificed at each time-point for retinal histology. ERG data were compared between groups and time-points using anova.RESULTS:
No complications were reported from either eye of any rabbits over a 6-month period. Photopic A wave was reduced in the control eye at 1 month compared with baseline (p < 0.01). There was no significant difference in other ERG parameters between the groups at different time-points. Gross retinal histology was normal at all time-points.CONCLUSION:
Extended release intravitreal brimonidine device was found to be safe and in normotensive rabbit eyes.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Quinoxalinas
/
Corpo Vítreo
/
Portadores de Fármacos
/
Anti-Hipertensivos
Limite:
Animals
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article