Corpus callosum atrophy--a simple predictor of multiple sclerosis progression: a longitudinal 9-year study.
Eur Neurol
; 68(1): 23-7, 2012.
Article
em En
| MEDLINE
| ID: mdl-22677920
ABSTRACT
AIM:
To determine whether corpus callosum atrophy predicts future clinical deterioration in multiple sclerosis.METHODS:
In 39 multiple sclerosis patients the area of corpus callosum in the sagittal plane, T2 and T1 lesion volumes, brain parenchymal fraction and brain atrophy were determined at baseline and 1 year after treatment initiation. Non-parametric and multiple regression models were built to identify the most reliable predictors of disability and of its changes over 9 years.RESULTS:
Corpus callosum atrophy during the first year of treatment was the best predictor of disability (r = -0.56) and of its increase at 9 years (r = 0.65). Corpus callosum atrophy of at least 2% predicted increase in disability with 93% sensitivity and 73% specificity (odds ratio = 35).CONCLUSION:
Corpus callosum atrophy is a simple and accurate predictor of future disability accumulation and is feasible for routine clinical practice.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Corpo Caloso
/
Esclerose Múltipla Recidivante-Remitente
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Adult
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Female
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Humans
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Male
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article