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Analyzing coronary artery disease in patients with low CAC scores by 64-slice MDCT.
Lu, Nan-Han; Yeh, Lee-Ren; Chen, Tai-Been; Huang, Yung-Hui; Kuo, Chung-Ming; Ding, Hueisch-Jy.
Afiliação
  • Lu NH; Department of Information Engineering, I-Shou University, Kaohsiung City 84001, Taiwan.
ScientificWorldJournal ; 2012: 907062, 2012.
Article em En | MEDLINE | ID: mdl-22701374
ABSTRACT

PURPOSE:

Coronary artery calcification (CAC) scores are widely used to determine risk for Coronary Artery Disease (CAD). A CAC score does not have the diagnostic accuracy needed for CAD. This work uses a novel efficient approach to predict CAD in patients with low CAC scores. MATERIALS AND

METHODS:

The study group comprised 86 subjects who underwent a screening health examination, including laboratory testing, CAC scanning, and cardiac angiography by 64-slice multidetector computed tomographic angiography. Eleven physiological variables and three personal parameters were investigated in proposed model. Logistic regression was applied to assess the sensitivity, specificity, and accuracy of when using individual variables and CAC score. Meta-analysis combined physiological and personal parameters by logistic regression.

RESULTS:

The diagnostic sensitivity of the CAC score was 14.3% when the CAC score was ≤30. Sensitivity increased to 57.13% using the proposed model. The statistically significant variables, based on beta values and P values, were family history, LDL-c, blood pressure, HDL-c, age, triglyceride, and cholesterol.

CONCLUSIONS:

The CAC score has low negative predictive value for CAD. This work applied a novel prediction method that uses patient information, including physiological and society parameters. The proposed method increases the accuracy of CAC score for predicting CAD.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença da Artéria Coronariana / Calcinose / Interpretação de Imagem Radiográfica Assistida por Computador / Tomografia Computadorizada por Raios X / Angiografia Coronária Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2012 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença da Artéria Coronariana / Calcinose / Interpretação de Imagem Radiográfica Assistida por Computador / Tomografia Computadorizada por Raios X / Angiografia Coronária Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2012 Tipo de documento: Article