[Protocol for administration of trastuzumab based on cardiac function].
Gan To Kagaku Ryoho
; 39(6): 915-9, 2012 Jun.
Article
em Ja
| MEDLINE
| ID: mdl-22705685
ABSTRACT
We analyzed 7 patients with breast cancer who suffered from trastuzumab-associated cardiac dysfunction. Left ventricular ejection fraction (EF) was calculated by M-mode echocardiography. We propose a protocol for the administration of trastuzumab based on EF in the clinical courses of the 7 patients and the literatures concernig trastuzumab. If the EF is ≥60%, an echocardiography is performed every 3 months during trastuzumab therapy. If the EF is ≥53% and ≤60%, an echocardiography is performed every 2 months. If the EF is ≤53%, an echocardiography is performed more frequently. If the EF decreases by ≥10% from its previous level, an echocardiography is performed after 3 weeks. Also, trastuzumab is withheld when the EF falls to ≤45%. When the EF falls to ≤40%, the standard treatment for congestive heart failure is initiated. An echocardiography is performed every 2 weeks after trastuzumab is withheld. Trastuzumab therapy can be resumed if the EF improves to ≥50%.
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Mama
/
Disfunção Ventricular Esquerda
/
Anticorpos Monoclonais Humanizados
Tipo de estudo:
Diagnostic_studies
/
Guideline
Limite:
Adult
/
Aged80
/
Female
/
Humans
/
Middle aged
Idioma:
Ja
Ano de publicação:
2012
Tipo de documento:
Article