[Efficacy of triple therapy in patients with chronic hepatitis C not treated and patients previously treated ineffectively]. / Skutecznosc terapii trójlekowej u chorych przewlekle zakazonych HCV, nieleczonych i z nieskuteczna wczesniejsza terapia.
Przegl Epidemiol
; 66(1): 49-54, 2012.
Article
em Pl
| MEDLINE
| ID: mdl-22708298
ABSTRACT
Since ten years pegylated interferon alpha and ribavirin (PR) are a standard treatment for the patients with chronic HCV infection. Recently, new drugs emerge called direct-acting antivirals. The first of them, telaprevir (TVR) and boceprevir (BOC), which peptidomimetic NS3/4A HCV serine protease inhibitors, have been recorded this year in Europe. Adding them to the PR significantly increases efficacy of standard treatment and creates the possibility of its reduction. This paper presents, based on the results of the third phase studies, the efficacy of triple therapy in selected groups of patients. Also includes current recommendations for treatment with BOC or TVR in combination with PR.
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Eixos temáticos:
Pesquisa_clinica
Base de dados:
MEDLINE
Assunto principal:
Antivirais
/
Oligopeptídeos
/
Prolina
/
Inibidores de Serina Proteinase
/
Hepacivirus
/
Hepatite C Crônica
Tipo de estudo:
Guideline
Limite:
Humans
País como assunto:
Europa
Idioma:
Pl
Ano de publicação:
2012
Tipo de documento:
Article