[Immune activity of heat shock protein gp96 and its application in active immunotherapy for tumor and infectious diseases].
Sheng Wu Gong Cheng Xue Bao
; 28(3): 261-6, 2012 Mar.
Article
em Zh
| MEDLINE
| ID: mdl-22712385
ABSTRACT
Heat-shock protein gp96 associates with antigenic peptides derived from tumor and virus. Exogenous gp96-peptide complexes are taken up by antigen-presenting cells through interaction with its receptor CD91 on the cell surface, and cross-present antigenic peptides to MHC class I molecules by a peptide relay line in the endoplasmic reticulum for specific T-cell activation. Meanwhile, gp96 has been shown to initiate innate immune responses through interaction with toll-like receptor 2 and toll-like receptor 4. Recent studies have shown a gp96-mediated immune balance between CTL and Tregs. With the further understanding of counteracting immunosuppressive mechanisms in gp96-induced cellular immune responses, and establishment of high level production of recombinant gp96 by the yeast, gp96 appears to be a promising candidate for designing effective therapeutic vaccines against tumor and infectious diseases.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Doenças Transmissíveis
/
Imunoterapia Ativa
/
Proteínas de Choque Térmico
/
Neoplasias
Limite:
Animals
/
Humans
Idioma:
Zh
Ano de publicação:
2012
Tipo de documento:
Article