The faces and friends of RhoGDI2.
Cancer Metastasis Rev
; 31(3-4): 519-28, 2012 Dec.
Article
em En
| MEDLINE
| ID: mdl-22718398
ABSTRACT
RhoGDI2 is a guanine nucleotide dissociation inhibitor (GDI) specific for the Rho family of small GTPases that plays dual opposite roles in tumor progression, being both a promoter in tissues such as breast and a metastasis suppressor in tissues such as the bladder. Despite a clear role for this protein in modulating the invasive and metastatic process, the mechanisms through which RhoGDI2 executes these functions remain unclear. This review will highlight the current state of our knowledge regarding how RhoGDI2 functions in metastasis with a focus on bladder cancer and will also seek to highlight other potential underappreciated avenues through which this protein may affect cancer cell behavior.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Inibidor beta de Dissociação do Nucleotídeo Guanina rho
/
Metástase Neoplásica
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article