Lack of efficacy of a starch-thickened preterm formula on gastro-oesophageal reflux in preterm infants: a pilot study.
J Matern Fetal Neonatal Med
; 25(12): 2735-8, 2012 Dec.
Article
em En
| MEDLINE
| ID: mdl-22725606
ABSTRACT
BACKGROUND:
Gastro-oesophageal reflux (GOR) is common in preterm infants; conservative interventions (i.e. dietary changes) should represent the first-line approach.AIM:
To evaluate by combined pH and impedance monitoring (pH-MII) the effect of a new preterm formula thickened with amylopectin (TPF) on GOR features in symptomatic preterm infants.METHODS:
Twenty-eight symptomatic preterm newborns underwent a 24-hour pH-MII; each baby received eight meals (four of TPF and four of a preterm formula [PF]). GOR indexes (number, acidity, duration and height of GORs) after TPF and PF meals were compared by Wilcoxon Signed Ranks Test. Viscosity of PF and TPF was measured.RESULTS:
TPF significantly decreased the number of acid GORs detected by pH-monitoring (TPF vs. PF median 20 vs. 24.5, p = 0.009), while it had no influence on Reflux Index (RIpH), nor on acid and non-acid GOR indexes detected by MII, GOR physical features, and GOR height. TPF's viscosity was extremely higher than PF's, and further increased at pH 3 after the addition of pepsin.CONCLUSIONS:
The new formula was found to reduce the number of acid GORs detected by pH-monitoring; it did not reduce neither total oesophageal acid exposure nor non-acid GORs. At present its extended clinical use cannot be recommended.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Amido
/
Refluxo Gastroesofágico
/
Fórmulas Infantis
/
Doenças do Prematuro
Tipo de estudo:
Diagnostic_studies
Limite:
Female
/
Humans
/
Male
/
Newborn
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article