An expeditious synthesis of the MDM2-p53 inhibitor AM-8553.
J Am Chem Soc
; 134(30): 12855-60, 2012 Aug 01.
Article
em En
| MEDLINE
| ID: mdl-22734631
ABSTRACT
The development of the structurally complex MDM2/p53 inhibitor AM-8553 was impeded by the low yield of the initial synthesis. A second generation synthesis is described that features a Noyori dynamic kinetic resolution, a highly diastereoselective allylation, and a novel oxazoline-assisted piperidinone forming reaction to provide AM-8553 in 35.6% yield and 11 steps.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Piperidonas
/
Proteína Supressora de Tumor p53
/
Proteínas Proto-Oncogênicas c-mdm2
/
Acetatos
/
Antineoplásicos
Limite:
Humans
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article