Novel cytotoxic polyoxygenated steroids from an Okinawan sponge Dysidea sp.
Biosci Biotechnol Biochem
; 76(5): 999-1002, 2012.
Article
em En
| MEDLINE
| ID: mdl-22738973
ABSTRACT
A library of extracts established from hundreds of marine organisms was screened by a cytotoxicity test. The active organic extract of an Okinawan marine sponge of the genus Dysidea was subjected to bioassay-guided fractionation to give three new polyoxygenated steroids dysideasterols F-H (1-3), together with two known related compounds (4 and 5). Their structures were confirmed by NMR and mass spectroscopic analyses. A characteristic structural feature of 2, 4 and 5 is an allylic epoxide, whereas this epoxide undergoes ring-opening by a neighbouring hydroxyl group to give a tetrahydrofuran ring in 1 and 3. All compounds 1-5 exhibited a similar cytotoxic effect with IC50 values of 0.15-0.3 µM against human epidermoid carcinoma A431 cells, demonstrating that the allylic epoxide moiety was not responsible for this cytotoxic effect.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Esteróis
/
Dysidea
/
Organismos Aquáticos
/
Antineoplásicos
Limite:
Animals
/
Humans
País como assunto:
Asia
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article