Conservation of a unique mechanism of immune evasion across the Lyssavirus genus.
J Virol
; 86(18): 10194-9, 2012 Sep.
Article
em En
| MEDLINE
| ID: mdl-22740405
The evasion of host innate immunity by Rabies virus, the prototype of the genus Lyssavirus, depends on a unique mechanism of selective targeting of interferon-activated STAT proteins by the viral phosphoprotein (P-protein). However, the immune evasion strategies of other lyssaviruses, including several lethal human pathogens, are unresolved. Here, we show that this mechanism is conserved between the most distantly related members of the genus, providing important insights into the pathogenesis and potential therapeutic targeting of lyssaviruses.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Lyssavirus
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article