Small molecule-gold nanorod conjugates selectively target and induce macrophage cytotoxicity towards breast cancer cells.
Small
; 8(18): 2819-22, 2012 Sep 24.
Article
em En
| MEDLINE
| ID: mdl-22777707
ABSTRACT
Gold nanoparticles are known to activate anti-tumor potential in macrophage immune cells; however, the subsequent effects of these cells on others nearby are poorly understood. A novel gold-nanoparticle conjugate that selectively targets and induces cytotoxic activity of tumor-associated macrophages towards breast cancer cells in co-culture is synthesized. These constructs are promising new tools for studying fundamental biological interactions with nanoscale materials and candidates for emerging macrophage-mediated delivery applications.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Macrolídeos
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Citotoxicidade Imunológica
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Nanotubos
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Nanopartículas Metálicas
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Ouro
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Macrófagos
Limite:
Animals
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article