Cooperative assistance in bifunctional organocatalysis: enantioselective Mannich reactions with aliphatic and aromatic imines.
Angew Chem Int Ed Engl
; 51(34): 8495-9, 2012 Aug 20.
Article
em En
| MEDLINE
| ID: mdl-22777736
ABSTRACT
Hold them tight Guided by X-ray structures, bifunctional thiourea catalysts containing an activating intramolecular hydrogen bond were redesigned. The new catalysts were used to effect a highly enantioselective Mannich reaction between malonates and both aliphatic and aromatic imines (see scheme; Boc=tert-butoxycarbonyl).
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Aminoácidos
/
Iminas
/
Malonatos
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article