Genome-wide analysis reveals that Smad3 and JMJD3 HDM co-activate the neural developmental program.
Development
; 139(15): 2681-91, 2012 Aug.
Article
em En
| MEDLINE
| ID: mdl-22782721
ABSTRACT
Neural development requires crosstalk between signaling pathways and chromatin. In this study, we demonstrate that neurogenesis is promoted by an interplay between the TGFß pathway and the H3K27me3 histone demethylase (HDM) JMJD3. Genome-wide analysis showed that JMJD3 is targeted to gene promoters by Smad3 in neural stem cells (NSCs) and is essential to activate TGFß-responsive genes. In vivo experiments in chick spinal cord revealed that the generation of neurons promoted by Smad3 is dependent on JMJD3 HDM activity. Overall, these findings indicate that JMJD3 function is required for the TGFß developmental program to proceed.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Biologia do Desenvolvimento
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Regulação da Expressão Gênica
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Proteína Smad3
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Estudo de Associação Genômica Ampla
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Histona Desmetilases com o Domínio Jumonji
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Neurônios
Tipo de estudo:
Prognostic_studies
Limite:
Animals
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Humans
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article