Insights into the virulence of oral biofilms: discoveries from proteomics.
Expert Rev Proteomics
; 9(3): 311-23, 2012 Jun.
Article
em En
| MEDLINE
| ID: mdl-22809209
ABSTRACT
This review covers developments in the study of polymicrobial communities, biofilms and selected areas of host response relevant to dental plaque and related areas of oral biology. The emphasis is on recent studies in which proteomic methods, particularly those using mass spectrometry as a readout, have played a major role in the investigation. The last 5-10 years have seen a transition of such methods from the periphery of oral biology to the mainstream, as in other areas of biomedical science. For reasons of focus and space, the authors do not discuss biomarker studies relevant to improved diagnostics for oral health, as this literature is rather substantial in its own right and deserves a separate treatment. Here, global gene regulation studies of plaque-component organisms, biofilm formation, multispecies interactions and host-microbe interactions are discussed. Several aspects of proteomics methodology that are relevant to the studies of multispecies systems are commented upon.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Biofilmes
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Proteômica
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Placa Dentária
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Interações Hospedeiro-Patógeno
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Bactérias Anaeróbias Gram-Negativas
Limite:
Humans
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article