Developing T-cell migration: role of semaphorins and ephrins.
FASEB J
; 26(11): 4390-9, 2012 Nov.
Article
em En
| MEDLINE
| ID: mdl-22815386
ABSTRACT
Cell migration is a crucial event for normal T-cell development, and various ligand/receptor pairs have been implicated. Most of them, including chemokines and extracellular matrix proteins, have attractant properties on thymocytes. We discuss herein two further groups of ligand/receptor pairs, semaphorins/neuropilins and ephs/ephrins, which are constitutively expressed by thymocytes and thymic microenvironmental cells. Evidence shows that the corresponding interactions are relevant for developing T-cell migration, including the entry of bone marrow progenitor cells, migration of CD4/CD8-defined thymocyte subpopulations triggered by chemokines and/or extracellular matrix proteins, and thymocyte export. Conceptually, the data summarized here show that thymocyte migration results from a complex network of molecular interactions, which generate not only attraction, but also repulsion of migrating T-cell precursors.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Movimento Celular
/
Efrinas
/
Semaforinas
/
Timócitos
Limite:
Animals
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article