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Eudesmane-type sesquiterpenoid and guaianolides from Kandelia candel in a screening program for compounds to overcome TRAIL resistance.
Minakawa, Tomohiro; Toume, Kazufumi; Arai, Midori A; Sadhu, Samir K; Ahmed, Firoj; Ishibashi, Masami.
Afiliação
  • Minakawa T; Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chiba 260-8675, Japan.
J Nat Prod ; 75(8): 1431-5, 2012 Aug 24.
Article em En | MEDLINE | ID: mdl-22823026
ABSTRACT
In a screening program for natural products that can overcome TRAIL resistance, a new eudesmane-type sesquiterpenoid (1), three new guaianolides, mehirugins A-C (2-4), and two known guaianolides (5 and 6) were isolated from a MeOH extract of Kandelia candel leaves. Compounds 1 and 3-6 in combination with TRAIL showed cytotoxic activity in sensitizing TRAIL-resistant human gastric adenocarcinoma cells.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Rhizophoraceae / Sesquiterpenos de Eudesmano / Receptores do Ligante Indutor de Apoptose Relacionado a TNF Tipo de estudo: Diagnostic_studies / Screening_studies Limite: Humans País como assunto: Asia Idioma: En Ano de publicação: 2012 Tipo de documento: Article
Texto completo
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Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Rhizophoraceae / Sesquiterpenos de Eudesmano / Receptores do Ligante Indutor de Apoptose Relacionado a TNF Tipo de estudo: Diagnostic_studies / Screening_studies Limite: Humans País como assunto: Asia Idioma: En Ano de publicação: 2012 Tipo de documento: Article