Insulin sensitivity modulates the growth response during the first year of high-dose growth hormone treatment in short prepubertal children born small for gestational age.
Horm Res Paediatr
; 78(1): 24-30, 2012.
Article
em En
| MEDLINE
| ID: mdl-22832126
AIM: To study the relationship between insulin sensitivity and growth response in short children born small for gestational age (SGA) treated with growth hormone (GH). METHODS: Randomized, open-label, 24-month intervention study in 40 short prepubertal SGA children [age (mean ± SD) 5.3 ± 1.5 years], who either remained untreated (n = 20) or were treated with GH (66 µg/kg/day; n = 20). Changes in fasting glucose, insulin, quantitative insulin sensitivity check index (QUICKI), IGF-1 and leptin after 1 and 2 years were studied. RESULTS: Mean height SDS increased from -3.3 ± 0.7 to -2.3 ± 0.7 after 1 year, and to -1.9 ± 0.7 after 2 years of treatment. QUICKI decreased significantly (p = 0.008) in the first year of GH treatment and stabilized in the second year. Baseline QUICKI was positively associated (r = 0.40; p < 0.05) with the change in height SDS in the first year. CONCLUSION: Higher insulin sensitivity at the start of GH therapy is associated with greater first-year growth response to GH, and could be a promising parameter in selecting prepubertal short SGA children for GH treatment. However, this finding needs to be confirmed in larger studies.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Recém-Nascido Pequeno para a Idade Gestacional
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Resistência à Insulina
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Desenvolvimento Infantil
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Hormônio do Crescimento Humano
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Transtornos do Crescimento
Tipo de estudo:
Clinical_trials
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Diagnostic_studies
Limite:
Child
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Child, preschool
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Female
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Humans
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Male
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Newborn
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article