Modulation of DNA repair by pharmacological inhibitors of the PIKK protein kinase family.
Bioorg Med Chem Lett
; 22(17): 5352-9, 2012 Sep 01.
Article
em En
| MEDLINE
| ID: mdl-22835870
ABSTRACT
Modulation of DNA repair pathways in oncology has been an area of intense interest in the last decade, not least as a consequence of the promising clinical activity of poly(ADP-ribose) polymerase (PARP) inhibitors. In this review article, we highlight inhibitors of the phosphatidylinositol 3-kinase related kinase (PIKK) family as of potential interest in the treatment of cancer, both in combination with DNA-damaging therapies and as stand-alone agents.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteínas Serina-Treonina Quinases
/
Inibidores de Proteínas Quinases
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Reparo do DNA
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Neoplasias
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article