The RIG-I-like receptor LGP2 controls CD8(+) T cell survival and fitness.
Immunity
; 37(2): 235-48, 2012 Aug 24.
Article
em En
| MEDLINE
| ID: mdl-22841161
ABSTRACT
The RIG-I-like receptors (RLRs) signal innate immune defenses upon RNA virus infection, but their roles in adaptive immunity have not been clearly defined. Here, we showed that the RLR LGP2 was not essential for induction of innate immune defenses, but rather was required for controlling antigen-specific CD8(+) T cell survival and fitness during peripheral T cell-number expansion in response to virus infection. Adoptive transfer and biochemical studies demonstrated that T cell-receptor signaling induced LGP2 expression wherein LGP2 operated to regulate death-receptor signaling and imparted sensitivity to CD95-mediated cell death. Thus, LGP2 promotes an essential prosurvival signal in response to antigen stimulation to confer CD8(+) T cell-number expansion and effector functions against divergent RNA viruses, including West Nile virus and lymphocytic choriomeningitis virus.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
RNA Viral
/
Sobrevivência Celular
/
Linfócitos T CD8-Positivos
/
RNA Helicases
/
Imunidade Adaptativa
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article