Two distinct channels of olfactory bulb output.
Neuron
; 75(2): 320-9, 2012 Jul 26.
Article
em En
| MEDLINE
| ID: mdl-22841316
ABSTRACT
Rhythmic neural activity is a hallmark of brain function, used ubiquitously to structure neural information. In mammalian olfaction, repetitive sniffing sets the principal rhythm but little is known about its role in sensory coding. Here, we show that mitral and tufted cells, the two main classes of olfactory bulb projection neurons, tightly lock to this rhythm, but to opposing phases of the sniff cycle. This phase shift is established by local inhibition that selectively delays mitral cell activity. Furthermore, while tufted cell phase is unperturbed in response to purely excitatory odorants, mitral cell phase is advanced in a graded, stimulus-dependent manner. Thus, phase separation by inhibition forms the basis for two distinct channels of olfactory processing.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Bulbo Olfatório
/
Condutos Olfatórios
/
Olfato
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Percepção Olfatória
/
Neurônios
Limite:
Animals
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article