Xenotropic and polytropic murine leukemia virus-related sequences are not detected in the majority of patients with chronic fatigue syndrome.
New Microbiol
; 35(3): 341-4, 2012 Jul.
Article
em En
| MEDLINE
| ID: mdl-22842604
ABSTRACT
XMRV and polytropic MLV-related virus have been controversially associated with chronic fatigue syndrome (CFS). Subsequent reports failed to detect XMRV and MLV-related virus in CFS patients, and the previous results have been interpreted as a massive laboratory contamination by mouse DNA sequences. Among 12 sequential CFS patients, two were positive for XMRV/MLV sequences. In contrast, 40 selected control subjects were negative. CSF patients and controls were negative for mitochondrial mouse-specific DNA sequences. These findings do not confirm the high frequency of MLV-related viruses infection in CFS patients, but also contrast the widespread laboratory contamination previously suggested.
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Base de dados:
MEDLINE
Assunto principal:
Síndrome de Fadiga Crônica
/
Genes gag
/
Infecções por Retroviridae
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Vírus Relacionado ao Vírus Xenotrópico da Leucemia Murina
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Genes Virais
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article