Intrarenal urothelial transformation after obstruction: a novel metaplasia.
Kidney Int
; 82(4): 377-9, 2012 Aug.
Article
em En
| MEDLINE
| ID: mdl-22846812
ABSTRACT
Obstructive nephropathy is a major cause of acute renal failure and end-stage renal disease. We discuss the new findings of Girshovich et al., who show that transformation of intrarenal urothelium into a bladder-like urothelium depends on the activation of the FGF7-FGFR2 signaling pathway following acute ureteral obstruction. A possible link between hypoxia-inducible factor 1α and the FGF-FGFR signaling pathway is suggested.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Obstrução Ureteral
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Bexiga Urinária
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Diferenciação Celular
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Urotélio
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Proliferação de Células
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Transdiferenciação Celular
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Rim
Limite:
Animals
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article