Antimicrobials that affect the synthesis and conformation of nucleic acids.
Rev Sci Tech
; 31(1): 77-87, 65-76, 2012 Apr.
Article
em En, Fr
| MEDLINE
| ID: mdl-22849269
ABSTRACT
Several antimicrobials act by inhibiting the synthesis of nucleic acids (rifamycins, sulfamides, diaminopyridines), modifying their conformation (quinolones, coumarins) or causing irreversible lesions (nitroimidazoles, nitrofurans). The resistance mechanisms are a reduction in intracytoplasmic accumulation, modification of the target or the production of a new low-affinity target and, more rarely, enzyme inactivation. Although the mechanisms affecting the targets are specific to each family and can lead to high-level resistance, the reduced permeability of the membrane and the increased efflux are non-specific and result in low-level cross-resistance between several families. The genetic mediation is usually chromosomal for rifamycins and quinolones, although plasmid-mediated resistant genes have been observed. On the other hand, for sulfamides and trimethoprim, plasmid-borne genes are frequent. Resistance to nitroimidazoles and nitrofurans is still not widely understood.
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Base de dados:
MEDLINE
Assunto principal:
Ácidos Nucleicos
/
Anti-Infecciosos
/
Conformação de Ácido Nucleico
Idioma:
En
/
Fr
Ano de publicação:
2012
Tipo de documento:
Article