Increased susceptibility to Salmonella infection in signal regulatory protein α-deficient mice.
J Immunol
; 189(5): 2537-44, 2012 Sep 01.
Article
em En
| MEDLINE
| ID: mdl-22851710
ABSTRACT
Recent studies have shed light on the connection between elevated erythropoetin production/spleen erythropoiesis and increased susceptibility to Salmonella infection. In this article, we provide another mouse model, the SIRPα-deficient (Sirpαâ»/â») mouse, that manifests increased erythropoiesis as well as heightened susceptibility to Salmonella infection. Sirpαâ»/â» mice succumbed to systemic infection with attenuated Salmonella, possessing significantly higher bacterial loads in both the spleen and the liver. Moreover, Salmonella-specific Ab production and Ag-specific CD4 T cells were reduced in Sirpαâ»/â» mice compared with wild-type controls. To further characterize the potential mechanism underlying SIRPα-dependent Ag-specific CD4 T cell priming, we demonstrate that lack of SIRPα expression on dendritic cells results in less efficient Ag processing and presentation in vitro. Collectively, these findings demonstrate an indispensable role of SIRPα for protective immunity to Salmonella infection.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Infecções por Salmonella
/
Receptores Imunológicos
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Regulação para Cima
/
Predisposição Genética para Doença
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article