The influence of clinical and anthropometric parameters on the serum levels of the endothelin-1 in pregnant women and their newborns.
Coll Antropol
; 36(2): 395-400, 2012 Jun.
Article
em En
| MEDLINE
| ID: mdl-22856221
ABSTRACT
Pregnancy induced hypertension (PIH) is major contributor to maternal death in developing countries. Endothelin-1 (ET-1) is the most potent vasoconstriction agent known and its serum levels are increased in PIH. Therefore it is important to elucidate maternal and neonatal factors which influence endothelin-1 serum levels. 100 pathological pregnancies and 88 controls were analyzed for blood endothelin-1 and their anthropometric and clinical data were collected. In maternal blood ET-1 levels were strongly predicted by diagnosis, therapy and BMI, while umbilical cord ET-1 levels were strongly predicted by gestational age, therapy and delivery termination. Positive correlation between BMI and ET-1 levels suggest that obese pregnant women have increased risk for cardiovascular diseases. Inverse relationship between Apgar and umbilical ET-1 indicates that ET-1 could be considered as a prognostic marker in cases of neonatal asphyxia.
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Base de dados:
MEDLINE
Assunto principal:
Asfixia Neonatal
/
Antropometria
/
Endotelina-1
/
Hipertensão Induzida pela Gravidez
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Male
/
Newborn
/
Pregnancy
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article