Rh-catalyzed intermolecular carbenoid functionalization of aromatic C-H bonds by α-diazomalonates.
J Am Chem Soc
; 134(33): 13565-8, 2012 Aug 22.
Article
em En
| MEDLINE
| ID: mdl-22860697
ABSTRACT
A Rh-catalyzed intermolecular coupling of diazomalonates with arene C-H bonds is reported. The reaction is initiated by electrophilic C-H activation, which is followed by coupling of the arylrhodium(III) complex with the diazomalonate. In most cases, arenes with oximes, carboxylic acids, and amines as directing groups cross-couple with diazomalonates with excellent regioselectivities and functional group tolerance, and thus, this reaction offers a new route to α-aryl carbonyl compounds for specific applications.
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MEDLINE
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article