Generating an iPSC bank for HLA-matched tissue transplantation based on known donor and recipient HLA types.
Cell Stem Cell
; 11(2): 147-52, 2012 Aug 03.
Article
em En
| MEDLINE
| ID: mdl-22862941
ABSTRACT
The likelihood for immunological rejection of Human Leukocyte Antigens (HLA)-mismatched induced pluripotent stem cells (iPSCs) limits their therapeutic potential. Here we show how a tissue bank from 150 selected homozygous HLA-typed volunteers could match 93% of the UK population with a minimal requirement for immunosuppression. Our model provides a practical approach for using existing HLA-typed samples to generate an iPSC stem cell bank that circumvents prospective typing of a large number of individuals.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Doadores de Tecidos
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Teste de Histocompatibilidade
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Transplante de Células-Tronco
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Células-Tronco Pluripotentes Induzidas
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Antígenos HLA
Limite:
Humans
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article