Severe tuberculosis in patients with human immunodeficiency virus infection.
Intensive Care Med
; 16(8): 491-3, 1990.
Article
em En
| MEDLINE
| ID: mdl-2286728
ABSTRACT
Tuberculosis has now been well documented as a complication of infection with human immunodeficiency virus (HIV), but no studies concern patients requiring admission to the ICU. We report 12 cases of severe disseminated tuberculosis in patients who were seropositive for HIV. Eight patients had diffuse pulmonary involvement responsible for acute respiratory failure, 7 of whom required mechanical ventilation. Four developed septic shock, and in 3 blood cultures were positive for M. tuberculosis. Four patients had central nervous system involvement, with coma requiring mechanical ventilation 3 times. Rapid diagnosis was permitted in 10 patients by acid-fast smears of pulmonary specimens (8 patients) and/or tissue biopsies (4 patients). Seven patients died despite intensive therapy; autopsy was performed in 4 patients, showing disseminated tuberculosis. On the basis of this report, tuberculosis in HIV infection may present as an overwhelming systemic disease and thus requires an aggressive diagnostic and therapeutic approach.
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Base de dados:
MEDLINE
Assunto principal:
Tuberculose
/
Infecções Oportunistas
/
Síndrome da Imunodeficiência Adquirida
/
Unidades de Terapia Intensiva
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Adult
/
Humans
/
Male
País como assunto:
Europa
Idioma:
En
Ano de publicação:
1990
Tipo de documento:
Article