Prevalence and clinical impact of norovirus fecal shedding in children with inherited immune deficiencies.
J Infect Dis
; 206(8): 1269-74, 2012 Oct.
Article
em En
| MEDLINE
| ID: mdl-22872736
ABSTRACT
We report the first prospective study describing the prevalence and clinical consequences of norovirus infection in hospitalized children with primary immunodeficiencies. Fecal samples from 62 children were systematically screened for virus. Norovirus was the most frequent pathogen (11 of 24 positive samples) found in both combined and humoral immunocompromised children. Norovirus shedding was associated with gastrointestinal symptoms and concomitant viremia in 54.5% and 25% of cases, respectively. Norovirus excretion was prolonged 57.1% of fecal samples were still positive after a median of 9.5-months follow-up. Further large longitudinal studies are needed to evaluate the clinical consequences of norovirus shedding in patients with primary immunodeficiencies.
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Base de dados:
MEDLINE
Assunto principal:
Eliminação de Partículas Virais
/
Infecções por Caliciviridae
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Norovirus
/
Fezes
/
Gastroenterite
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Síndromes de Imunodeficiência
Tipo de estudo:
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Limite:
Child
/
Child, preschool
/
Female
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Humans
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Infant
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Male
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Newborn
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article