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Impaired processing of 3D motion-defined faces in mild cognitive impairment and healthy aging: an fMRI study.
Graewe, Britta; Lemos, Raquel; Ferreira, Carlos; Santana, Isabel; Farivar, Reza; De Weerd, Peter; Castelo-Branco, Miguel.
Afiliação
  • Graewe B; Department of Cognitive Neuroscience, Faculty of Psychology & Neuroscience, Maastricht University, PO Box 616, 6200 MD Maastricht, the Netherlands.
Cereb Cortex ; 23(10): 2489-99, 2013 Oct.
Article em En | MEDLINE | ID: mdl-22879351
Mild cognitive impairment (MCI), which shows high risk for conversion to Alzheimer's disease (AD), is accompanied by progressive visual deteriorations that so far are poorly understood. Here, we compared dorsal and ventral visual stream functional magnetic resonance imaging (fMRI) activity among amnestic MCI, healthy elderly, and young participants during structure-from-motion (SFM) face categorization performance. Task performance varied with stimulus depth and duration levels and differences among groups were highly correlated with face-related fMRI activation patterns. Young participants showed larger activation to faces than scrambled faces (face sensitivity) in the right fusiform face area (FFA) and right occipital face area (OFA) whereas in elderly, this difference was reduced. Surprisingly, in MCI, scrambled faces elicited larger activation in right FFA/OFA than faces. The latter observation may be related to the additional finding of elevated depth sensitivity in left FFA/OFA of MCI, suggesting that an increased representation of low-level stimulus aspects may impair face perception in MCI. Discriminant function analysis using face and depth sensitivity indices in FFA/OFA classified MCI and healthy elderly with 88.2% accuracy, marking a fundamental distinction between groups. Potentially related findings include altered activation patterns in dorsal-ventral stream integration regions and attention-related networks of MCI patients. Our results highlight aberrant visual and additional potentially compensatory processes that identify dispositions of (preclinical) AD.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Córtex Visual / Envelhecimento / Disfunção Cognitiva / Percepção de Movimento Tipo de estudo: Prognostic_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2013 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Córtex Visual / Envelhecimento / Disfunção Cognitiva / Percepção de Movimento Tipo de estudo: Prognostic_studies Limite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2013 Tipo de documento: Article