Vitamin D receptor gene polymorphisms in type 1 diabetes mellitus: a new pattern from Khorasan Province, Islamic Republic of Iran.
East Mediterr Health J
; 18(6): 614-9, 2012 Jun.
Article
em En
| MEDLINE
| ID: mdl-22888618
ABSTRACT
Reported associations between vitamin D receptor (VDR) polymorphism and type 1 diabetes mellitus vary across ethnic groups. We studied the association between type 1 diabetes and 4 VDR gene polymorphisms (Bb, Ff Aa and Tt) in an Iranian population. A group of 69 patients with type 1 diabetes mellitus and 45 unrelated healthy subjects were recruited. The prevalence of VDR polymorphisms in 4 restriction fragment length polymorphism sites including Bsml, Fokl, Apal and Taql were analysed in patients and controls. The frequencies of 3 genotypes (Aa, FF and Bb) were significantly higher in the patient group. The relationship between VDR gene polymorphisms and onset pattern of diabetes was not significant. There were no significant difference between the genotype frequencies and chronic complications of diabetes, but the relationship between the Ffgenotype and ketoacidosis was significant. Our results differ from previous polymorphism studies in other regions.
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Base de dados:
MEDLINE
Assunto principal:
Receptores de Calcitriol
/
Diabetes Mellitus Tipo 1
Tipo de estudo:
Etiology_studies
/
Prevalence_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Male
País como assunto:
Asia
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article