Retinol levels are associated with magnetic resonance imaging outcomes in multiple sclerosis.
Mult Scler
; 19(4): 451-7, 2013 Apr.
Article
em En
| MEDLINE
| ID: mdl-22907941
ABSTRACT
BACKGROUND:
Vitamin A has immunomodulatory properties and may regulate the transcription of genes involved in remyelination.OBJECTIVE:
To investigate the association between retinol and disease activity in multiple sclerosis (MS).METHODS:
Cohort study of 88 relapsing-remitting MS patients, originally included in a randomised placebo-controlled trial of omega-3 fatty acids in MS (the OFAMS study), followed prospectively for 24 months with repeated assessments of serum-retinol and magnetic resonance imaging (MRI). All patients were initiated on interferon ß-1a after month 6.RESULTS:
Each 1 µmol/L increase in serum-retinol reduced the odds (95% confidence interval) for new T1 gadolinium enhanced (Gd(+)) lesions by 49 (8-70)%, new T2 lesions by 42 (2-66)%, and combined unique activity (CUA) by 46 (3-68)% in simultaneous MRI scans, and 63 (25-82)% for new T1Gd(+) lesions, 49 (3-73)% for new T2 lesions and 43 (12-71)% for CUA the subsequent month. Serum-retinol also predicted new T1Gd(+) and T2 lesions six months ahead. The associations were not affected by HLA-DRB1*15, or serum levels of 25-hydroxyvitamin D, eicosapentaenoic acid or docosahexaenoic acid.CONCLUSION:
Serum retinol is inversely associated with simultaneous and subsequent MRI outcomes in RRMS.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Vitamina A
/
Esclerose Múltipla Recidivante-Remitente
Tipo de estudo:
Clinical_trials
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article