Anti-inflammatory properties of a triterpenoidal glycoside from Momordica cochinchinensis in LPS-stimulated macrophages.
Immunopharmacol Immunotoxicol
; 35(1): 8-14, 2013 Feb.
Article
em En
| MEDLINE
| ID: mdl-22916793
ABSTRACT
Two triterpenoidal saponins were isolated from the seeds of Momordica cochinchinensis Sprenger (Cucurbitaceae). Identification of chemical structures has been performed by (1)H- and (13)C-NMR spectroscopy and gas chromatography (GC). One of the saponins is a new gypsogenin glycoside, named as gypsogenin 3-O-ß-D-galactopyranosyl(1â2)-[α-L-rhamnopyranosyl(1â3)]-ß-D-glucuronopyranoside (compound 1), which is reported for the first time from natural resources. The other saponin is a quillaic acid glycoside (compound 2), which showed anti-inflammatory activities in RAW 264.7 cells. The mechanistic understanding of anti-inflammatory activities demonstrates that compound 2 inhibits lipopolysaccharide-induced expression of nitric oxide and IL-6 via NF-κB pathway.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Terpenos
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Triterpenos
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Lipopolissacarídeos
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Momordica
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Glicosídeos
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Macrófagos
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Anti-Inflamatórios
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article