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Structure-activity relationship of a broad-spectrum insect odorant receptor agonist.
Taylor, Robert W; Romaine, Ian M; Liu, Chao; Murthi, Poornima; Jones, Patrick L; Waterson, Alex G; Sulikowski, Gary A; Zwiebel, Laurence J.
Afiliação
  • Taylor RW; Department of Biological Sciences, Vanderbilt Institute of Chemical Biology, Vanderbilt University, Nashville, Tennessee 37235, United States.
ACS Chem Biol ; 7(10): 1647-52, 2012 Oct 19.
Article em En | MEDLINE | ID: mdl-22924767
Agonism of insect odorant receptor (OR) cation channels may represent a new strategy for the manipulation of destructive insect olfactory-driven behaviors. We have explored the chemical space around VUAA1, the first in class agonist of the obligate OR co-receptor ion channel (Orco), and describe novel compound analogues with increased potency across insect taxa. Functional analyses reveal several of these VUAA1 structural analogues display significantly greater potency as compared to the activity of the previously described active compounds in mobility-based behavioral assays on mosquito larvae.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tioglicolatos / Triazóis / Receptores Odorantes / Anopheles Limite: Animals / Humans Idioma: En Ano de publicação: 2012 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tioglicolatos / Triazóis / Receptores Odorantes / Anopheles Limite: Animals / Humans Idioma: En Ano de publicação: 2012 Tipo de documento: Article