Low postnatal serum IGF-I levels are associated with bronchopulmonary dysplasia (BPD).
Acta Paediatr
; 101(12): 1211-6, 2012 Dec.
Article
em En
| MEDLINE
| ID: mdl-22924869
ABSTRACT
AIM:
To characterize postnatal changes in serum insulin-like growth factor-1 (IGF-I) in relation to development of bronchopulmonary dysplasia (BPD) in very preterm infants.METHODS:
Longitudinal study of 108 infants with mean (SD) gestational age (GA) 27.2 (2.2) weeks. Weekly serum samples of IGF-I were analysed from birth until postmenstrual age (PMA) 36 weeks. Multivariate models were developed to identify independent predictors of BPD.RESULTS:
Postnatal mean IGF-I levels at postnatal day (PND) 3-21 were lower in infants with BPD compared with infants with no BPD (16 vs. 26 µg/L, p < 0.001). Longitudinal postnatal change in IGF-I levels (IGF-I regression coefficient (ß)), PNDs 3-21, was lower in infants with BPD compared with infants with no BPD (0.28 vs. 0.97, p = 0.002) and mean IGF-I during PMA 30-33 weeks was lower in infants with BPD as compared with infants without BPD (22 vs. 29 µg/L, p < 0.001). In a binomial multiple regression model, lower GA, male gender and lower mean serum IGF-I levels during PND 3-21 were the most predictive risk factors associated with BPD (r(2) = 0.634, p < 0.001).CONCLUSION:
Lower IGF-I concentrations during the first weeks after very preterm birth are associated with later development of BPD.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Displasia Broncopulmonar
/
Fator de Crescimento Insulin-Like I
Tipo de estudo:
Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Female
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Humans
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Male
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Newborn
Idioma:
En
Ano de publicação:
2012
Tipo de documento:
Article